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The FDA has continued revising the label since: January 28, 2025 added acute kidney injury and severe gastrointestinal reaction warnings along with “not recommended in patients with severe gastroparesis,” and October 14, 2025 strengthened the pancreatitis warnings
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These findings highlight substantial heterogeneity in SUD comorbidity patterns, with alcohol–nicotine related-disorders representing the most prevalent pairing in this population ( Supplementary Figure 1 )
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