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In 5 years, obesity drugs went from 15% weight loss (Wegovy) to 29% (Retatrutide). But efficacy is only half the story. Look at the pipeline: 50+ drugs across 8+ distinct mechanisms. GLP-1s

MOTS-C does it directly, by suppressing TNF-alpha, IL-6, and IL-1 beta at the cellular level

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Although basal levels of HGP were unchanged, insulin-stimulated HGP was significantly lower in HFHC-fed Dpp4 –/– (Figure 1C), resulting in a significantly greater suppression of HGP by insulin in Dpp4 –/– mice (Figure 1D)