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Frontiers | Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion

Key contributors include urbanization, an aging population, decreasing levels of physical activity, and increased levels of overweight and obesity

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Loading involves taking 20 grams per day divided into four doses for five to seven days, which saturates muscle creatine stores quickly, followed by a maintenance dose of 3 to 5 grams daily