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Comprehensive Metabolic Panel (CMP) Why it matters: The CMP is arguably the most essential single panel before GLP-1 initiation because it assesses both kidney function and liver function simultaneously — the two organ systems most relevant to medication safety monitoring

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While it does activate GLP-1 receptors like semaglutide, it has five times stronger affinity for GIP receptors, creating a metabolic signal your body doesn't get from GLP-1 medications alone

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