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the administration of N-acetyl-GIP and N-pyroglutamyl-GIP resulted in an attenuation of hyperglycemia in ob/ob mice [125], and several other GIP analogues have been reported to improve glucose tolerance in both lean and obese mice [126-128]
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However, some clinical evidences suggest that GLP-1RA therapy could potentially increase the risk of colorectal cancer in a subset of patients [38]
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