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Glp1r SAN−/− and Gcgr SAN−/− mice and controls (wild type, Cre, floxed) were produced by breeding Hcn4-Cre hemizygous mice with floxed Glp1r mice [18]or floxed Gcgr mice [19], respectively

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This helps you feel full longer and lowers blood sugar, but it also slows how other substances (like meds or nutrients) get absorbed