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In 2025, Novo Nordisk’s semaglutide awaits several first-time FDA decisions: 3Q 2025 – the first GLP-1 (Wegovy) for metabolic dysfunction-associated steatohepatitis (MASH) 4Q 2025 – the first oral GLP-1 ( oral formulation of Wegovy 25 mg ) for weight loss and weight loss plus secondary CV risk reduction 4Q 2025 – Wegovy for heart failure with preserved ejection fraction and obesity October 2025 – new indication for oral Rybelsus for secondary CV risk reduction 2025 – Ozempic for T2DM and peripheral artery disease (PAD) Given the considerable continued growth expected in the GLP-1 pipeline, Prime Therapeutic’s (Prime) talented team of clinical experts actively monitors this emerging landscape