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This model of body fat regulation was widely adopted in the 1990s with the discovery of leptin [3,4]

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While the risk of initiating TNF-α inhibitors (adjusted IRR: 0.56, 95% CI: 0.32–1.00) and IBD-related surgery (adjusted IRR: 0.79, 95% CI: 0.57–1.09) was also reduced, these associations were not statistically significant