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The DPP-4 inhibitor isoleucin-thiazolidide was found to augment insulin secretion and improve glucose tolerance in association with prolonging the half-life of GLP-1 in lean and obese Zucker rats (41)

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hormonal contraception can regulate if bothersome Lighter, shorter, or skipped periods: Likely mechanism: improved insulin sensitivity restoring or altering ovulatory patterns Typical timeline: starts week 4 to 8, may persist as new baseline if PCOS was underlying issue Associated findings: history of irregular cycles pre-treatment, elevated baseline hemoglobin A1c, acanthosis nigricans What it means: metabolic improvement is changing your ovulation pattern