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Amgen's weight-loss drug fails to impress in study; shares plunge | Reuters

“I find it difficult to imagine GLP-1 medications being prescribed solely for depression,” Mir Ali, MD, medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California, tells SELF

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A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism