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however, this group reported that alpha-cells with this immature transcriptional profile also exhibited an impaired electrophysiological phenotype and dysregulated exocytosis ( In addition to these findings that specific alpha-cell subtypes may contribute to disease progression, recent evidence has fostered the similar hypothesis that the heterogenous proliferative state, maturity, and secretory phenotypes of alpha-cells primes various subpopulations for cell-type conversions ( Figure 3 )