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In the case, the sister’s modest weight improvement may benefit from female-specific hormonal environments (e.g., estrogen) that enhance GLP-1 receptor signaling, while the brother’s limited response could be related to male-specific factors that blunt semaglutide-induced appetite suppression and energy expenditure regulation

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[10] Rapper Lizzo, who is referenced in the episode, reacted in a video post on Instagram, "Guys, my worst fear has been actualized