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doi:10.1053/j.gastro.2017.04.022 Cornejo-Pareja I, Martín-Núñez GM, Roca-Rodríguez MM, et al
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The working mechanism is that skin sensory nerves turn up their response to a signal they already carry, rather than the drug creating new pain signaling (selective ATP/P2X amplification²⁷)
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