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A large body of evidence on GLP-1RAs has demonstrated that these agents are safe (noninferiority to placebo in addition to standard care) and effective (glycemic control), with a minimal risk of hypoglycemic episodes and a significantly reduced risk of major adverse cardiovascular events (MACEs), all-cause mortality, and hospitalization for heart failure following their administration, as well as a slowing of renal dysfunction [2]
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[20] The use of clarithromycin and sildenafil is not recommended due to the potential increased sildenafil concentrations due to the CYP3A4 inhibition of clarithromycin