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Notably, in healthy human volunteers, acute administration of GLP-1, GLP-1 (9-36amide), or exenatide did not affect blood flow in the mesenteric or renal arteries, excluding splanchnic vasodilatation as a potential mechanism underlying the chronic hypotensive effect of GLP-1 [644]

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Novo Nordisk’s CagriSema, a fixed-dose combination rather than a single multi-receptor peptide, remains under FDA review, with a decision expected in late 2026 and no action date publicly confirmed