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This happens through a series of steps involving specific enzymes called prohormone convertases which cut the proglucagon into smaller pieces – one of which is GLP-1

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( a-c ) Representative histological images from of sections with antibody labeling for mCherry (magenta) or DCZ-induced Fos (green) and DAPI (blue) from Control (n = 4 mice) ( a ), Gs-Dreadd (n = 4 mice) ( b ), or Gq-Dreadd (n = 6 mice) ( c ) mice