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TheCut just released an article on one of the long-term side effects of GLP-1s - anhedonia: the inability to feel pleasure from normal human activities. Anhedonia is the primary symptom of depression.
In lean subjects, infusion of GLP-1 7-36 amide led to a 13.2% reduction in energy intake at the ad libitum buffet meal compared with saline infusion
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The gross margin on oral Wegovy is below that of the injectable, Novo CFO Karsten Knudsen said on an earnings call in February