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The oral form overcomes the limitations of peptide instability in the gastrointestinal tract through the use of the absorption enhancer SNAC (sodium N-[8-(2-hydroxybenzoyl)aminocaprylate]), which allows the half-life of oral semaglutide to reach approximately 1 week (160 h), aligning with the subcutaneously administered form [88,89]
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Those receiving the drug lost about 25 pounds on average, vs
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