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In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF-γ (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors
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Obesity raises the risk of gallstones in general, but data from clinical trials have shown that people on GLP-1 treatments have a 37 percent higher relative risk of developing gallbladder disease, which can include the formation of gallstones
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