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While all three medications are GLP-1 agonists, there are key differences: Active Ingredients: Zepbound contains tirzepatide, a dual agonist that targets both GIP and GLP-1 receptors

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It included metformin (n=139), insulin (n=63), DPP-4 inhibitors (n=23), sulfonylureas (n=12), SGLT2 inhibitors (n=6), thiazolidinediones (n=2) and repaglinide (n=3)