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Frontiers | Association between GLP-1 receptor agonist use and substance use disorders among individuals with type 2 diabetes or obesity: a nested case-control study in the All of Us research program

Effects of glucagon-like peptide-1 receptor agonist exendin-4 on the reinstatement of cocaine-mediated conditioned place preference in mice

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Ozempic (semaglutide) is a GLP-1 receptor agonist manufactured by Novo Nordisk: FDA approval: 2017 for Type 2 diabetes Dosing: Weekly subcutaneous injection (0.25mg, 0.5mg, 1.0mg, or 2.0mg) Device: Multi-dose pen requiring dose dialing Mechanism: Activates GLP-1 receptors to improve blood sugar control and reduce appetite Related products: Wegovy: Same semaglutide at higher dose (2.4mg), FDA-approved for weight management Rybelsus: Oral semaglutide for diabetes How GLP-1 Medications Work Both medications work through the same pathway: Appetite reduction: Act on brain regions controlling hunger and satiety Reduce appetite between meals Enhance feelings of fullness after eating Glucose regulation: Stimulate insulin release when blood sugar is elevated (glucose-dependent) Suppress glucagon release (reduces liver glucose output) Slow gastric emptying (reduces post-meal glucose spikes) Cardiovascular effects: Reduce inflammation Improve blood vessel function Lower blood pressure Reduce cardiovascular event risk Despite working through the same GLP-1 receptor pathway, different medications produce different effects based on their specific molecular structures and binding characteristics