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Semaglutide Weight Loss Results Semaglutide produces greater and more sustained weight loss: STEP trial data (semaglutide 2.4mg): Average weight loss: 14.9% of body weight over 68 weeks 86% of participants lost at least 5% 69% lost at least 10% 50% lost at least 15% 32% lost at least 20% What this means practically: For someone weighing 220 pounds: Average result: 33 pounds lost (reaching 187 pounds) Good responder: 44+ pounds lost (reaching 176 pounds or lower) Timeline: Over 15-18 months, with continued maintenance With continued treatment: Weight loss is maintained as long as medication continues
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